One of the problems with Web 2.0 (and more specifically AJAX’ed applications) is their lack of usability for people with different types of disabilities. AJAX (aka Asynchronous Javascript over XML aka snazzy things done behind the browser screen) is an example of technology that has been adopted widely with graceful accessibility trying very hard to catch up.
Not all is bad news, Google for one is working very hard (and so are other companies such as Yahoo!